Proceedings of the American Pharmaceutical Association at the Annual Meeting Volume 31-39

Proceedings of the American Pharmaceutical Association at the Annual Meeting Volume 31-39 by American Pharmaceutical Association

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Author: American Pharmaceutical Association
Page Count: 446 pages
Published Date: 01 Mar 2012
Publisher: Rarebooksclub.com
Publication Country: Miami Fl, United States
Language: English
ISBN: 9781130389524
File Name: Proceedings.of.the.American.Pharmaceutical.Association.at.the.Annual.Meeting.Volume.31-39.pdf
Download Link: Proceedings of the American Pharmaceutical Association at the Annual Meeting Volume 31-39
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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1891 Excerpt: ... heated for some time with water at 8o C, it gradually disappears and is not again precipitated on cooling. The solution, which is of distinctly acid reaction, now contains benzoylecgonine and ecgonine, as well as cocaine benzoate: the benzoic acid being formed in not inconsiderable quantity, and, combining with the cocaine, prevents its further decomposition, and effects its solution. Benzoylecgonine, produced under the above named conditions, crystallizes out of hot concentrated aqueous solutions upon cooling in glassy prisms. It dissolves very easily in alcohol and wood spirit, is fairly soluble in hot acetone and chloroform, and crystallizes out of the latter solution, when cold, in long needles. Ecgonine.--If cocaine or benzoylecgonine be heated with excess of hydrochloric acid upon a sand-bath to about 8oC, benzoic acid separates from the solution upon cooling, and after its removal ecgonine hydrochloride crystallizes from the evaporated filtrate, and may be obtained pure by recrystallization from hot 93 per cent, alcohol, forming cubical anhydrous crystals. The base itself may be separated by digesting the hydrochloride with oxide of silver, removing excess of silver by sulphuretted hydrogen, and evaporating the filtrate. It is difficultly soluble in hot chloroform, benzoic methylester or aceto-acetic ester, but crystallizes unaltered from the solvents on cooling. It is readily soluble in water, and its solution has a perfectly neutral reaction. Coca/nine.--This was discovered by the author in the " Paris variety " of coca above referred to (see Proceedings 1888, 555). He originally attributed to it the formula Cl7H;iNO but has since found it necessary to correct and double the formula, viz., C1, H), iN.J0, +H;,0. Cocamine dissolves re...

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